pdf THE NT-1505 EFFECT ON THE ENDOPLASMIC RETICULUM MEMBRANES STRUCTURE IN VIVO Популярные

N.Yu. Gerasimov, O.V. Nevrova, V.V. Kasparov, A.L. Kovarskii, A.N. Goloshchapov,

E.B. Burlakova

IBCP RAS,Moscow, Russia

The results on research of the neuroprotector NT-1505 influence on endoplasmic reticulum (ER) membranes are presented in this paper. It is shown that the dynamics of changes of lipidic and near-protein areas of ER membranes microviscosity has antibate character after drug administration what indicates on the absence of pathological disturbances in the membrane structure. Relative changes of microviscosity of the near-protein and lipidic areas of ER membranes were differently directed in relation to control on all periods of drug injection that is usually observed in norm. Membrane microviscosity was measured by electron paramagnetic resonance spin labeling of 2,2,6,6-tetramethyl-4-capryloyl-oxypiperidine-1-oxyl (lipid probe) and 5,6-benzo-2,2,6,6-tetramethyl-1,2,3,4-tetrahydro-γ-carboline-3-oxyl (near protein probe).