pdf THE EFFECT OF PERSPECTIVE NEUROPROTECTORS ON FLUIDITY OF SYNAPTOSOMAL MEMBRANES IN VIVO Популярные

Nevrova O.V., Gerasimov N.Yu., Goloshchapov A.N., Kasparov V.V., Kovarskii A.L.,

Burlakova E.B.

IBCP RAS, Moscow, Russia

In this work membrane fluidity alterations in synaptosomes, isolated from mice brain tissue, at chronic administration of perspective neuroprotectors Dimebon and NT-1505 in vivo were studied. Membrane microviscosity was measured by electron paramagnetic resonance spin labeling of 2,2,6,6-tetramethyl-4-capryloyl-oxylpiperidine-1-oxyl and 5,6-benzo-2,2,6,6-tetramethyl-1,2,3,4-tetrahydro-γ-carboline-3-oxyl. It was shown that the neuroprotectors Dimebon and NT-1505 affect a membrane structure. Despite the difference in membrane structures, fluidity of the lipid bilayer in time returned to control values. Consequently, the microviscosity of membranes plays an important role in the cell metabolism and comes to be an important structural characteristic. In this way, during assorting preparations for therapy of diseases one should take into account the change in lability and structure of membranes, which, possibly, will allow avoiding side actions and elevating the effectiveness of medicinal means.